Bilateral gonadoblastoma producing steroid hormones in a patient with 45,X/46,XY gonadal dysgenesis.

A case of bilateral gonadoblastoma in a phenotypic female with 45,X/46,XY gonadal dysgenesis is presented. Hormonal investigations revealed that serum testosterone, estradiol and beta-human chorionic gonadotropin decreased following excision of the tumors, but follicle-stimulating hormone and luteinizing homrone levels increased further. Immunohistochemical staining for testosterone and estradiol was positive in both Leydig and lutein-like cells in the tumor. It is suggested that gonadoblastoma is capable of producing testosterone and estradiol, and Leydig or lutein-like cells may be the actual source of these steroid hormones.
AuthorsY Fukamatsu, Y Tsukahara, S Hayashi, F Yoshikawa, T Fukuta
JournalGynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 30 Issue 3 Pg. 189-91 ( 1990) ISSN: 0378-7346 [Print] SWITZERLAND
PMID1702401 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Chorionic Gonadotropin
  • Chorionic Gonadotropin, beta Subunit, Human
  • Peptide Fragments
  • Testosterone
  • Estradiol
  • Adolescent
  • Chorionic Gonadotropin (secretion)
  • Chorionic Gonadotropin, beta Subunit, Human
  • Dysgerminoma (pathology, secretion)
  • Estradiol (secretion)
  • Female
  • Gonadal Dysgenesis, Mixed (complications, pathology)
  • Gonads (pathology)
  • Humans
  • Immunoenzyme Techniques
  • Neoplasms, Multiple Primary (pathology, secretion)
  • Peptide Fragments (secretion)
  • Testosterone (secretion)

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