Abstract | BACKGROUND AND PURPOSE: METHODS: Participants (N=6456) of the Rotterdam Study were included in the current study. Analyses of the relations of genotypes with the risk of myocardial infarction and stroke were performed according to Cox proportional-hazards methods. All analyses were adjusted for age, sex, conventional cardiovascular risk factors, and medical history. RESULTS: We found no association with the risk of myocardial infarction. A significantly increased risk of stroke was found, associated with the T allele of the -509 C/T polymorphism (relative risk, 1.26; (95% CI, 1.06 to 1.49) and the Pro variant of the codon 10 polymorphism (relative risk, 1.24; 95% CI, 1.04 to 1.48). CONCLUSIONS:
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Authors | Mark P S Sie, André G Uitterlinden, Michiel J Bos, Pascal P Arp, Monique M B Breteler, Peter J Koudstaal, Huibert A P Pols, Albert Hofman, Cornelia M van Duijn, Jacqueline C M Witteman |
Journal | Stroke
(Stroke)
Vol. 37
Issue 11
Pg. 2667-71
(Nov 2006)
ISSN: 1524-4628 [Electronic] United States |
PMID | 17023672
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- TGFB1 protein, human
- Transforming Growth Factor beta
- Transforming Growth Factor beta1
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Topics |
- Aged
- Aged, 80 and over
- Alleles
- Cohort Studies
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
(genetics)
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(epidemiology, genetics)
- Netherlands
- Polymorphism, Genetic
(genetics)
- Prospective Studies
- Risk Factors
- Stroke
(epidemiology, genetics)
- Transforming Growth Factor beta
(genetics)
- Transforming Growth Factor beta1
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