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TGF-beta 1 polymorphisms and risk of myocardial infarction and stroke: the Rotterdam Study.

AbstractBACKGROUND AND PURPOSE:
Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and of cardiovascular and cerebrovascular complications. Transforming growth factor-beta1 (TGF-beta1) is a pleiotropic cytokine with a central role in inflammation. Little is known of the relation of variations within the gene and risk of cardiovascular and cerebrovascular disease. We therefore investigated 5 polymorphisms in the TGF-beta1 gene (-800 G/A, -509 C/T, codon 10 Leu/Pro, codon 25 Arg/Pro, and codon 263 Thr/Ile) in relation to the risk of myocardial infarction and stroke in a population-based study.
METHODS:
Participants (N=6456) of the Rotterdam Study were included in the current study. Analyses of the relations of genotypes with the risk of myocardial infarction and stroke were performed according to Cox proportional-hazards methods. All analyses were adjusted for age, sex, conventional cardiovascular risk factors, and medical history.
RESULTS:
We found no association with the risk of myocardial infarction. A significantly increased risk of stroke was found, associated with the T allele of the -509 C/T polymorphism (relative risk, 1.26; (95% CI, 1.06 to 1.49) and the Pro variant of the codon 10 polymorphism (relative risk, 1.24; 95% CI, 1.04 to 1.48).
CONCLUSIONS:
No association between the TGF-beta1 polymorphisms and myocardial infarction was observed; however, the -509 C/T and codon 10 Leu/Pro polymorphisms were associated with the risk of stroke.
AuthorsMark P S Sie, André G Uitterlinden, Michiel J Bos, Pascal P Arp, Monique M B Breteler, Peter J Koudstaal, Huibert A P Pols, Albert Hofman, Cornelia M van Duijn, Jacqueline C M Witteman
JournalStroke (Stroke) Vol. 37 Issue 11 Pg. 2667-71 (Nov 2006) ISSN: 1524-4628 [Electronic] United States
PMID17023672 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • TGFB1 protein, human
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1
Topics
  • Aged
  • Aged, 80 and over
  • Alleles
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease (genetics)
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction (epidemiology, genetics)
  • Netherlands
  • Polymorphism, Genetic (genetics)
  • Prospective Studies
  • Risk Factors
  • Stroke (epidemiology, genetics)
  • Transforming Growth Factor beta (genetics)
  • Transforming Growth Factor beta1

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