RNASEL gene polymorphisms and the risk of prostate cancer: a meta-analysis.

Abstract

PURPOSE:

Studies revealing conflicting results on the role of RNASEL polymorphisms Glu265X, Arg462Gln, and Asp541Glu on prostate cancer risk led us to perform a meta-analysis to investigate the association of these polymorphisms and prostate cancer risk.

EXPERIMENTAL DESIGN:

Relevant studies were selected by searching PubMed from January 1996 to August 2005 using keywords "RNASEL gene AND prostate cancer." For each study, odds ratio (OR) with 95% confidence interval (95% CI) was calculated to estimate the gene effect. Pooled estimates of the OR were computed using the random effects model.

RESULTS:

Ten studies were included in the meta-analysis. The overall results suggested no major influence of these variants on prostate cancer risk. However, analysis of the Asp541Glu polymorphism by ethnic populations showed that Asp/Glu (familial cases versus control: OR, 1.38; 95% CI, 1.04-1.82; sporadic cases versus control: OR, 1.26; 95% CI, 1.07-1.48; prostate cancer versus control: OR, 1.29; 95% CI, 1.12-1.48) and Asp/Glu + Glu/Glu (familial cases versus control: OR, 1.37; 95% CI, 1.10-1.70; sporadic cases versus control: OR, 1.24; 95% CI, 1.07-1.44; prostate cancer versus control: OR, 1.27; 95% CI, 1.13-1.44) increased prostate cancer risk in Caucasians, thus suggesting a dominant model for the Glu variant.

CONCLUSIONS:

Compared with the genotype Asp/Asp, the Glu variant at the Asp541Glu polymorphism increases prostate cancer risk by <2-fold in Caucasians, regardless of family history of the disease. This suggests that genuine genetic effects of this polymorphism may account for only a part of prostate cancer in the Caucasian population.

• Authors: Huihua Li, Bee Choo Tai
• Journal: Clinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res) Vol. 12 Issue 19 Pg. 5713-9 (Oct 01 2006) ISSN: 1078-0432 [Print] United States
• PMID: 17020975 (Publication Type: Comparative Study, Journal Article, Meta-Analysis)

Chemical References

• Antineoplastic Agents
• Endoribonucleases
• 2-5A-dependent ribonuclease

Topics

• Antineoplastic Agents
• Case-Control Studies
• Endoribonucleases (genetics)
• Genetic Predisposition to Disease
• Humans
• Male
• Mutation (genetics)
• Polymorphism, Genetic
• Prostate (enzymology)
• Prostatic Neoplasms (enzymology, genetics)
• Risk Factors