A new cyclotetrapeptide from marine fungus Trichoderma reesei.

Abstract	A new cyclotetrapeptide, trichoderide A, was isolated from the marine fungus Trichoderma reesei. The structure was identified by spectral methods, and the stereochemical assignments were made by chiral HPLC of the hydrolyzed compound. Trichoderide A showed moderate cytotoxity against human A375-S2 melanoma cell line.
Authors	Yi Sun, Li Tian, Yong-Fu Huang, Yi Sha, Yue-Hu Pei
Journal	Die Pharmazie (Pharmazie) Vol. 61 Issue 9 Pg. 809-10 (Sep 2006) ISSN: 0031-7144 [Print] Germany
PMID	17020165 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Amino Acids Antineoplastic Agents Peptides, Cyclic Tetrazolium Salts Thiazoles trichoderide A thiazolyl blue
Topics	Amino Acids (analysis) Antineoplastic Agents (chemistry, isolation & purification, pharmacology) Cell Line, Tumor Chromatography, High Pressure Liquid Chromatography, Thin Layer Drug Screening Assays, Antitumor Humans Hydrolysis Magnetic Resonance Spectroscopy Melanoma, Experimental (drug therapy) Peptides, Cyclic (chemistry, isolation & purification, pharmacology) Tetrazolium Salts Thiazoles Trichoderma (chemistry)

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