Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats.

Abstract

This study examined the effects of simvastatin (10 mg/ kg) and VULM 1457 (50 mg/kg), an ACAT inhibitor, in the heart model of 6 min ischemia followed by 10 min reperfusion injury in the diabetic-hypercholesterolaemic (DM-HCH) rats. In the DM-HCH rats, the incidence of ventricular tachycardia (VT) had a tendency to be increased, while ventricular fibrillation (VF) occurred in all diseased rats (p < 0.01). Simvastatin and VULM 1457 with the shown hypolipidemic effect, significantly (p < 0.01) suppressed a formation of VF (38% and 29%; respectively).

• Authors: A Adameová, M Kuzelová, V Faberová, P Svec
• Journal: Die Pharmazie (Pharmazie) Vol. 61 Issue 9 Pg. 807-8 (Sep 2006) ISSN: 0031-7144 [Print] Germany
• PMID: 17020164 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Cholesterol, Dietary
• Enzyme Inhibitors
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• VULM 1457
• Cholesterol
• Simvastatin
• Sterol O-Acyltransferase
• Clofibrate

Topics

• Animals
• Arrhythmias, Cardiac (etiology, prevention & control)
• Blood Glucose (metabolism)
• Cholesterol (blood, metabolism)
• Cholesterol, Dietary
• Clofibrate (analogs & derivatives, therapeutic use)
• Diabetes Mellitus, Experimental (complications, physiopathology)
• Enzyme Inhibitors (therapeutic use)
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)
• Hypercholesterolemia (chemically induced, complications, physiopathology)
• Male
• Myocardial Reperfusion Injury (pathology, prevention & control)
• Rats
• Rats, Wistar
• Reperfusion Injury (pathology, prevention & control)
• Simvastatin (therapeutic use)
• Sterol O-Acyltransferase (antagonists & inhibitors)