[From thrombin hypothesis to inflammation. Is it reality?].

Abstract

The classical pathophysiologic concept of the acute coronary syndromes is the coronary artery thrombosis as a consequence of rupture or vulnerable atherosclerotic plaques. Actually, it is also been considered that systemic inflammatory phenomenon play a central role in the plaque instability associated to the atherothrombotic activity of the tissue factor (TF). The thrombotic phenomenon is controlled by tissue factor, stimulating the way of the protease's active receptors (PAR) and cause a negative cycle between inflammation and coagulation.

• Authors: Héctor González Pacheco
• Journal: Archivos de cardiologia de Mexico (Arch Cardiol Mex) 2006 Apr-Jun Vol. 76 Suppl 2 Pg. S233-8 ISSN: 1405-9940 [Print] Mexico
• Vernacular Title: De la hipótesis de la trombina a la inflamación. Es una realidad?
• PMID: 17017108 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Thrombin

Topics

• Acute Disease
• Angina, Unstable (etiology)
• Coronary Artery Disease (complications)
• Humans
• Inflammation (complications)
• Myocardial Infarction (etiology)
• Syndrome
• Thrombin (physiology)