HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Doxycycline-induced staining of permanent adult dentition.

AbstractBACKGROUND:
Doxycycline is the most effective antibiotic for managing brucellosis. Although it is relatively free from side effects, complications involving the skin, nails and teeth may rarely be encountered.
METHODS:
Four patients with brucellosis developed yellow-brown discolouration of teeth following a 30-45 day course of doxycycline therapy during summer at a dose of 200mg/day.
RESULTS:
All four patients were diagnosed as having doxycycline-induced staining of the permanent dentition. In all cases, the staining completely resolved and the teeth recovered their original colour following abrasive dental cleaning.
CONCLUSIONS:
These observations indicate that the incidence of staining of the permanent dentition, as a complication of doxycycline, may be much higher than the literature indicates, especially if treatment is administered during summer months. Fortunately, this complication is reversible and does not require termination of doxycycline therapy. Complete resolution following abrasive cleaning may suggest that an extrinsic mechanism within the dental milieu may be involved in its pathogenesis. Strict avoidance of sunlight exposure during high-dose, long-term doxycycline therapy might prevent the development of this complication.
AuthorsE Ayaslioglu, E Erkek, A A Oba, E Cebecioğlu
JournalAustralian dental journal (Aust Dent J) Vol. 50 Issue 4 Pg. 273-5 (Dec 2005) ISSN: 0045-0421 [Print] Australia
PMID17016895 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Doxycycline
  • Rifampin
  • Streptomycin
Topics
  • Adolescent
  • Adult
  • Anti-Bacterial Agents (adverse effects, therapeutic use)
  • Brucellosis (drug therapy)
  • Child
  • Doxycycline (adverse effects)
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Rifampin (therapeutic use)
  • Streptomycin (therapeutic use)
  • Sunlight (adverse effects)
  • Tooth Discoloration (chemically induced, therapy)
  • Toothbrushing (methods)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: