| Abstract | OBJECTIVE: We used an established experimental model to evaluate the influence of intraperitoneal chemotherapy on the generation of laparoscopy-associated metastases and the effectiveness of chemotherapy. STUDY DESIGN: Twenty-four nude mice underwent laparoscopy with carbon dioxide insufflation and the instillation of a tumor cell suspension with or without paclitaxel into the peritoneal cavity. Mice were allocated to 1 of the following groups (8 mice to each group): (1) controls; (2) paclitaxel given during the operation; (3) paclitaxel given after the operation. Mice were killed 30 days after the procedure, and the peritoneal cavity and port sites were examined for the presence of tumors. RESULTS: Tumor implantation and port-site metastases were reduced more by the intraoperative intraperitoneal administration of paclitaxel during the operation than by administration after the operation. CONCLUSION: Intraoperative intraperitoneal administration of paclitaxel may decrease significantly the occurrence of port-site metastasis and intraperitoneal dissemination in an animal study. |
| Authors | Chyi-Long Lee, Nari Kay
(Affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Endoscopy, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan. chyilong at ms21.hinet.net)
|
| Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 195
Issue 5
Pg. 1278-81
(Nov 2006)
ISSN: 1097-6868 United States |
| PMID | 17014818
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Antineoplastic Agents, Phytogenic
- Paclitaxel
|
| Topics |
- Abdomen
(surgery)
- Animals
- Antineoplastic Agents, Phytogenic
(administration & dosage, pharmacology)
- Cell Line, Tumor
- Drug Administration Schedule
- Female
- Humans
- Injections, Intraperitoneal
- Intraoperative Period
- Laparoscopy
(adverse effects)
- Mice
- Mice, Nude
- Neoplasm Seeding
- Neoplasm Transplantation
- Ovarian Neoplasms
(pathology, secondary)
- Paclitaxel
(administration & dosage, pharmacology)
- Postoperative Period
|
