Influence of ibuprofen-arginine on serum levels of nitric oxide metabolites in patients with chronic low back pain--a single-blind, placebo controlled pilot trial (ISRCTN18723747).

Abstract

OBJECTIVE:

To determine whether ibuprofen-arginine has a cyclooxygenase-independent pain modulating property in addition to its known antiinflammatory effect.

METHODS:

Patients with chronic low back pain were randomly divided into 2 groups treated either with oral ibuprofen-arginine (400 mg) or with placebo. Blood was drawn from study subjects before, during, and after treatment and they were asked each time about the intensity of their pain. Concentrations of nitric oxide (NO) metabolites were determined.

RESULTS:

Twenty minutes after intake of ibuprofen-arginine, but not after placebo, there was a relevant and significant reduction of NO metabolites in serum. In both groups there was significant analgesic effect compared to baseline.

CONCLUSION:

An early lowering of the serum NO metabolite levels after ibuprofen-arginine administration could be detected in patients with chronic low back pain.

• Authors: Haiko Sprott, Renate E Gay, Beat A Michel, Steffen Gay
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 33 Issue 12 Pg. 2515-8 (Dec 2006) ISSN: 0315-162X [Print] Canada
• PMID: 17013995 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Drug Combinations
• Nitric Oxide
• Arginine
• Ibuprofen
• ibuprofen arginine

Topics

• Analgesics (therapeutic use)
• Arginine (therapeutic use)
• Chronic Disease
• Drug Combinations
• Female
• Humans
• Ibuprofen (therapeutic use)
• Low Back Pain (blood, drug therapy, physiopathology)
• Male
• Middle Aged
• Nitric Oxide (blood)
• Pain Measurement
• Pilot Projects
• Single-Blind Method
• Treatment Outcome