Beta-hydoxy-beta-methylbutyrate supplementation affects Walker 256 tumor-bearing rats in a time-dependent manner.

Abstract

BACKGROUND & AIMS:

Cancer cachexia affects intermediary metabolism with intense and general catabolism. Walker 256 tumor is a model injected either subcutaneously (Sc) or intraperitoneally (Ip), with different metabolic features. Beta-hydroxy beta-methylbutyrate (HMbeta) is a leucine metabolite with anti-catabolic properties, the aim of this study being to investigate its effects on metabolic parameters in both tumor models.

METHODS:

Controls (subcutaneous control group (ScC) and intraperitoneal control group (IpC)) and supplemented animals (subcutaneous supplemented group (ScS) and intraperitoneal supplemented group (IpS)) showed these results.

RESULTS:

Protein Sc values were (47.8%) lower than Ip groups. Sc group fat content was (65.16%) higher than Ip groups. Liver glycogen value for Sc groups was (38.4%) higher than Ip groups. Muscle glycogen value for Sc groups were (2.75 times) higher than Ip groups. Corticosterone and insulin values were lower (44.53%) and higher (45.94%), respectively, in Sc when compared with Ip groups. Glucose and lactate values for ScS were the lowest (61.7% and 41.53%) compared to other groups. ScC glutamine value was the highest (40.8%) of all groups. Glutamate Sc values were (42.65%) lower than Ip groups. Sc groups showed greater survival time compared with Ip groups. ScS group showed 100% increase in survival time when compared with ScC.

CONCLUSIONS:

HMbeta supplementation can increase survival time and promotes metabolic changes in cancer-bearing animals, but it seems to work in a time-dependent manner.

• Authors: Erico Chagas Caperuto, Ronaldo Vagner Tomatieli, Alison Colquhoun, Marília Cerqueira Leite Seelaender, Luis Fernando Bicudo Pereira Costa Rosa
• Journal: Clinical nutrition (Edinburgh, Scotland) (Clin Nutr) Vol. 26 Issue 1 Pg. 117-22 (Feb 2007) ISSN: 0261-5614 [Print] England
• PMID: 17011676 (Publication Type: Journal Article)

Chemical References

• Liver Glycogen
• Proteins
• Glycogen
• 3-Hydroxybutyric Acid

Topics

• 3-Hydroxybutyric Acid (administration & dosage)
• Adipose Tissue (metabolism)
• Animals
• Body Composition (drug effects, physiology)
• Cachexia (metabolism, mortality, prevention & control)
• Carcinoma 256, Walker (metabolism, mortality)
• Dietary Supplements
• Disease Models, Animal
• Energy Metabolism (drug effects, physiology)
• Glycogen (metabolism)
• Injections, Intraperitoneal
• Injections, Subcutaneous
• Liver Glycogen (metabolism)
• Male
• Proteins (metabolism)
• Rats
• Rats, Wistar
• Survival Rate
• Time Factors