Transfer of accelerated presbycusis by transplantation of bone marrow cells from senescence-accelerated mice.

Abstract

Until now, there has been no effective therapy for chronic sensorineural hearing impairment. This study investigated the role of bone marrow cells (BMCs) in cochlear dysfunction. BALB/c mice (2 months of age), a non-presbycusis-prone mouse strain, were lethally irradiated and then transplanted with BMCs from SAMP1 mice (2 months of age), a presbycusis-prone mouse strain. Acceleration of age-related hearing loss, early degeneration of spiral ganglion cells (SGCs) and impairment of immune function were observed in the recipient mice as well as in the SAMP1 mice. However, no spiral ganglion cells of donor (SAMP1) origin were detected in the recipient mice. These results indicated that accelerated presbycusis, cochlear pathology, and immune dysfunction of SAMP1 mice can be transferred to BALB/c recipient mice using allogeneic bone marrow transplantation (BMT). However, although the BMCs themselves cannot differentiate into the spiral ganglion cells (SGCs), they indirectly cause the degeneration of the SGCs. Further studies into the relationship between the inner ear cells and BMCs are required.

• Authors: Susumu Baba, Hiroshi Iwai, Muneo Inaba, Kohei Kawamoto, Mariko Omae, Toshio Yamashita, Susumu Ikehara
• Journal: Brain research (Brain Res) Vol. 1120 Issue 1 Pg. 93-9 (Nov 20 2006) ISSN: 0006-8993 [Print] Netherlands
• PMID: 17011530 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Aging (genetics)
• Animals
• BALB 3T3 Cells
• Bone Marrow Transplantation (immunology, methods)
• Cell Count
• Disease Models, Animal
• Evoked Potentials, Auditory, Brain Stem (physiology)
• Fluorescent Antibody Technique (methods)
• Hearing Loss, Sensorineural (genetics)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Mice, Mutant Strains
• Nerve Degeneration (genetics, pathology)
• Presbycusis (etiology, immunology, pathology, physiopathology)
• Radiation Chimera
• Spiral Ganglion (immunology, pathology, physiopathology)