Abstract | BACKGROUND: METHODS: Patients (n = 254) with a major Axis I psychiatric disorder and comorbid alcohol dependence were treated for 12 weeks in a medication study at three Veterans Administration outpatient clinics. Randomization included (1) open randomization to disulfiram or no disulfiram; and (2) double-blind randomization to naltrexone or placebo. This resulted in four groups: (1) naltrexone alone; (2) placebo alone; (3) disulfiram and naltrexone; or (4) disulfiram and placebo. Outcomes were measures of alcohol use, PTSD symptoms, alcohol craving, GGT levels and adverse events. RESULTS: 93 individuals (36.6%) met DSM-IV criteria for PTSD. Subjects with PTSD had better alcohol outcomes with active medication ( naltrexone, disulfiram or the combination) than they did on placebo; overall psychiatric symptoms of PTSD improved. Individuals with PTSD were more likely to report some side effects when treated with the combination. CONCLUSIONS:
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Authors | Ismene L Petrakis, James Poling, Carolyn Levinson, Charla Nich, Kathleen Carroll, Elizabeth Ralevski, Bruce Rounsaville |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 60
Issue 7
Pg. 777-83
(Oct 01 2006)
ISSN: 0006-3223 [Print] United States |
PMID | 17008146
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Alcohol Deterrents
- Narcotic Antagonists
- Naltrexone
- Disulfiram
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Topics |
- Adult
- Alcohol Deterrents
(administration & dosage)
- Alcoholism
(complications, drug therapy, psychology)
- Analysis of Variance
- Diagnosis, Dual (Psychiatry)
- Disulfiram
(administration & dosage)
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Humans
- Male
- Middle Aged
- Naltrexone
(administration & dosage)
- Narcotic Antagonists
(administration & dosage)
- Stress Disorders, Post-Traumatic
(complications, drug therapy, psychology)
- Temperance
- Treatment Outcome
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