Abstract | OBJECTIVE: DESIGN: Retrospective review. SETTING: Two university-based urology clinics. PATIENT(S): INTERVENTION(S): MAIN OUTCOME MEASURE(S): RESULT(S): Ten men who were evaluated for infertility were diagnosed with HH. Four had Kallmann's syndrome, four idiopathic HH, and two panhypopituitarism. Eight patients were azoospermic, and two were oligospermic on presentation. Three of the four men with adult-onset idiopathic HH responded to CC alone with increases in testosterone, FSH, and LH. Semen parameters in this group also improved, and two of the three men achieved pregnancies with CC alone. Out of the ten men actively attempting conception, four pregnancies were achieved. Three pregnancies (two with CC and one with gonadotropins) were in men diagnosed with adult-onset idiopathic forms of HH. CONCLUSION(S): Select patients with adult-onset idiopathic forms of HH may benefit from a trial of clomiphene citrate.
|
Authors | Scott J Whitten, Ajay K Nangia, Peter N Kolettis |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 86
Issue 6
Pg. 1664-8
(Dec 2006)
ISSN: 1556-5653 [Electronic] United States |
PMID | 17007848
(Publication Type: Journal Article)
|
Chemical References |
- Estrogen Antagonists
- Clomiphene
|
Topics |
- Adult
- Clomiphene
(therapeutic use)
- Estrogen Antagonists
(therapeutic use)
- Humans
- Hypogonadism
(complications, drug therapy)
- Infertility, Male
(etiology, prevention & control)
- Male
- Patient Selection
- Retrospective Studies
- Treatment Outcome
|