Standardization of an experimental murine model of invasive pulmonary aspergillosis.

Abstract

Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.

• Authors: Donald C Sheppard, John R Graybill, Laura K Najvar, Lisa Y Chiang, Thomas Doedt, William R Kirkpatrick, Rosie Bocanegra, Ana C Vallor, Thomas F Patterson, Scott G Filler
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 50 Issue 10 Pg. 3501-3 (Oct 2006) ISSN: 0066-4804 [Print] United States
• PMID: 17005844 (Publication Type: Evaluation Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Liposomes
• liposomal amphotericin B
• Amphotericin B

Topics

• Amphotericin B (therapeutic use)
• Animals
• Antifungal Agents (therapeutic use)
• Aspergillosis (drug therapy, microbiology, mortality)
• Aspergillus fumigatus (isolation & purification, pathogenicity)
• Disease Models, Animal
• Humans
• Liposomes
• Lung (microbiology)
• Lung Diseases, Fungal (drug therapy, microbiology, mortality)
• Mice
• Reproducibility of Results
• Treatment Outcome