Localized reactive angioendotheliomatosis.

Abstract

We present a unique case of a woman with multiple painful dermal lesions localized to the left upper quadrant of the body. Histological investigation revealed microvascular thrombosis with capillary-wall proliferation. Further investigation revealed a very high anticardiolipin IgG titre and a left subclavian stenosis, presumably providing the reduced blood flow and relative hypoxia to allow microthromboses to occur in the presence of a thrombophilic tendency. Similar clinical and histological features have been reported in patients with the antiphospholipid syndrome and cases of reactive angioendotheliomatosis (RAE). This case represents a unique variant of RAE.

• Authors: S Kirke, B Angus, P J L Kesteven, E Calonje, N Simpson
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 32 Issue 1 Pg. 45-7 (Jan 2007) ISSN: 0307-6938 [Print] England
• PMID: 17004988 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Anticardiolipin

Topics

• Antibodies, Anticardiolipin (blood)
• Aortic Valve Stenosis (complications)
• Female
• Hemangioendothelioma (etiology, pathology)
• Humans
• Middle Aged
• Neoplasms, Vascular Tissue (etiology, pathology)
• Protein C Deficiency (complications)
• Thrombosis (drug therapy)