HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Analgesic, antiinflammatory, and ulcerogenic studies of meloxicam solid dispersion prepared with polyethylene glycol 6000.

Abstract
Meloxicam is a nonsteroidal antiinflammatory drug, used in the treatment of rheumatoid arthritis and oestoarthritis. It is practically insoluble in water, leading to poor dissolution, variations in bioavailability, and gastric irritation on oral administration. In the attempt to reduce its gastric side effect and to increase aqueous solubility, physical mixture and solid dispersion of the drug were prepared with polyethylene glycol 6000. The analgesic, antiinflammatory, and ulcerogenic effects were assessed for physical mixture and solid dispersion in comparison with meloxicam alone. The results indicate that both physical mixture and solid dispersion possess better analgesic and antiinflammatory properties with less ulcerogenic potential when compared with pure meloxicam.
AuthorsS G Vijaya Kumar, D N Mishra
JournalMethods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) Vol. 28 Issue 7 Pg. 419-22 (Sep 2006) ISSN: 0379-0355 [Print] Spain
PMID17003846 (Publication Type: Comparative Study, Journal Article)
Copyright(c) 2006 Prous Science. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Dosage Forms
  • Thiazines
  • Thiazoles
  • Polyethylene Glycols
  • Carrageenan
  • Acetic Acid
  • Meloxicam
Topics
  • Abdominal Pain (chemically induced, prevention & control)
  • Acetic Acid (administration & dosage, toxicity)
  • Administration, Oral
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, chemistry, pharmacology)
  • Carrageenan (administration & dosage, toxicity)
  • Dosage Forms
  • Dose-Response Relationship, Drug
  • Drug Compounding
  • Female
  • Gastric Mucosa (drug effects, pathology)
  • Hindlimb (drug effects, physiopathology)
  • Inflammation (chemically induced, prevention & control)
  • Male
  • Meloxicam
  • Mice
  • Polyethylene Glycols (chemistry)
  • Rats
  • Rats, Wistar
  • Solubility
  • Stomach Ulcer (chemically induced, prevention & control)
  • Thiazines (administration & dosage, chemistry, pharmacology)
  • Thiazoles (administration & dosage, chemistry, pharmacology)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: