[Inhibitors of proteolytic enzymes in the blood serum of patients with diphyllobothriasis].

Abstract

The proteinase inhibitors alpha 1-protease inhibitor (alpha 1-antitrypsin) and alpha 2-macroglobulin have been determined in 24 patients with diphyllobothriasis (D. latum and D. dendriticum), with their activity expressed in conventional units per ml serum inhibiting or binding the activity of 1 unit of trypsin, respectively. The specific activity of alpha 1-protease inhibitor and alpha 2-macroglobulin proved to be twice (46.2%) and thrice (32.7%) lower, respectively, despite a significant decrease in the total protein serum level. The ratio between these 2 parameters was 9.86 +/- 1.4, it being equal to 5.3 +/- 0.12 in the control. The authors believe that the reduced activity of alpha 1-protease inhibitor may be a protective response of the host to the invasion. Reduced activity is suggested to promote to chronic intestinal inflammation. Decreased activity of alpha 2-macroglobulin is accounted for by damages in its synthesis by monocyte-macrophage elements and probably by enhanced binding with proteinases of the parasite.

• Authors: L A Gosteva
• Journal: Meditsinskaia parazitologiia i parazitarnye bolezni (Med Parazitol (Mosk)) 1990 Jul-Aug Issue 4 Pg. 29-31 ISSN: 0025-8326 [Print] Russia (Federation)
• Vernacular Title: Ingibitory proteoliticheskikh fermentov syvorotki krovi bol'nykh difillobotriozom.
• PMID: 1700263 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Blood Proteins
• Protease Inhibitors
• alpha 1-Antitrypsin
• alpha-Macroglobulins

Topics

• Blood Proteins (analysis)
• Clinical Enzyme Tests
• Diphyllobothriasis (diagnosis)
• Humans
• Protease Inhibitors (blood)
• alpha 1-Antitrypsin (analysis)
• alpha-Macroglobulins (analysis)