Fish venom (Pterios volitans) peptide reduces tumor burden and ameliorates oxidative stress in Ehrlich's ascites carcinoma xenografted mice.

Abstract

The present study was carried out to assess the effect of Pterios volitans venom (mixture of peptides) on Ehrlich's ascites carcinoma (EAC) and its influence on antioxidant status in the liver. Among six groups of albino mice, three were treated with sublethal doses of venom, along with the standard drug, 5-fluorouracil. In EAC-bearing mice, mean life span and antioxidants were significantly decreased, whereas, body weight, tumor volume, viable tumor cell count, lipid peroxidation and expression of proliferating cell nuclear antigen were significantly increased. These changes were brought back to near normal in treatment groups. The findings are further confirmed by histopathological observations.

• Authors: M Sri Balasubashini, S Karthigayan, S T Somasundaram, T Balasubramanian, V Viswanathan, P Raveendran, V P Menon
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 16 Issue 24 Pg. 6219-25 (Dec 15 2006) ISSN: 0960-894X [Print] England
• PMID: 17000104 (Publication Type: Journal Article)

Chemical References

• Fish Venoms

Topics

• Animals
• Carcinoma, Ehrlich Tumor (drug therapy, pathology, physiopathology)
• Fish Venoms (pharmacology, toxicity)
• Fishes
• Lethal Dose 50
• Mice
• Oxidative Stress (drug effects)
• Transplantation, Heterologous