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Intravenous immunoglobulin therapy in paraneoplastic neurological syndromes.

Abstract
Combining clinical and immunological information, a neurological syndrome can now be diagnosed as a "definite" or "possible" paraneoplastic syndrome according to the newly suggested diagnostic criteria of the PNS Euronetwork. Differentiated diagnosis of a paraneoplastic syndrome is essential for differential therapy in patients. According to the response to IVIG therapy, paraneoplastic disorders may be subgrouped in group A, a clinical response is the rule (prototype Lambert-Eaton myasthenic syndrome), and in group B, IVIG may be helpful in single patients and is indicated in specific clinical settings (prototype anti-Hu associated neurological syndromes). The mode of action of IVIG may range from direct anti-idiotype effect to indirect effects on the cellular part of the pathogenesis of paraneoplastic syndromes. Due to the therapeutic relevance, it is therefore important to diagnose a PND as early as possible, and start immunotherapy including IVIG immediately.
AuthorsRaymond Voltz
JournalJournal of neurology (J Neurol) Vol. 253 Suppl 5 Pg. V33-8 (Sep 2006) ISSN: 0340-5354 [Print] Germany
PMID16998752 (Publication Type: Journal Article, Review)
Chemical References
  • Immunoglobulins, Intravenous
Topics
  • Humans
  • Immunoglobulins, Intravenous (therapeutic use)
  • Paraneoplastic Polyneuropathy (diagnosis, drug therapy, immunology)

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