The effects of lindane poisoning on N-acetyldopamine and N-acetyl 5-hydroxytryptamine concentrations in the brain of Locusta migratoria L.

Abstract

High-performance liquid chromatography with electrochemical detection was used to measure N-acetyldopamine and N-acetyl 5-hydroxytryptamine in the cerebral ganglia of the African migratory locust, Locusta migratoria (fifth instar) exposed to lindane, a chlorinated insecticide. Locusts were poisoned by this insecticide in order to assess the effects of this neuroactive compound on these acetylated metabolites levels. Relatively low concentrations of N-acetyldopamine were observed in the cerebral ganglia. Incubation of ganglia resulted in increased concentrations of N-acetyldopamine and N-acetyl 5-hydroxytryptamine. Lindane significantly reduces N-acetyldopamine and N-acetyl 5-hydroxytryptamine levels in the cerebral ganglia. These results can be correlated with a decrease in N-acetyltransferase activity.

• Authors: B Moreteau, N Chaminade
• Journal: Ecotoxicology and environmental safety (Ecotoxicol Environ Saf) Vol. 20 Issue 1 Pg. 115-20 (Aug 1990) ISSN: 0147-6513 [Print] Netherlands
• PMID: 1699720 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Amines
• N-acetyldopamine
• Serotonin
• Hexachlorocyclohexane
• Arylamine N-Acetyltransferase
• N-acetylserotonin
• Dopamine

Topics

• Administration, Topical
• Amines (metabolism)
• Animals
• Arylamine N-Acetyltransferase (antagonists & inhibitors)
• Brain (metabolism)
• Brain Chemistry
• Dopamine (analogs & derivatives, metabolism)
• Grasshoppers (metabolism)
• Hexachlorocyclohexane (administration & dosage, poisoning)
• Serotonin (analogs & derivatives, metabolism)