Insulin-like growth factors and their binding proteins: review of functions and clinical applications.

Abstract

Insulin-like Growth Factors I & II (IGFs I & II) circulate in a concentration 1000 times that of insulin. The effect of these growth factors appears to be regulated by their binding proteins. The clinical usefulness of the IGFs resides currently in the growth hormone disease states and their treatment, as well as tumour related hypoglycemia. The growth hormone dependent binding protein (mol. wt 53kD) appears to possess a role in growth disorders, whereas the growth hormone independent binding protein (mol. wt 28kD) has recently been found to exert a role in glucose homeostasis.

• Authors: S I Yeoh
• Journal: Annals of the Academy of Medicine, Singapore (Ann Acad Med Singap) Vol. 19 Issue 4 Pg. 497-500 (Jul 1990) ISSN: 0304-4602 [Print] Singapore
• PMID: 1699469 (Publication Type: Journal Article, Review)

Chemical References

• Carrier Proteins
• Growth Inhibitors
• Insulin-Like Growth Factor Binding Proteins
• Insulin-Like Growth Factor I
• Insulin-Like Growth Factor II
• Octreotide

Topics

• Acromegaly (blood, etiology)
• Adolescent
• Carrier Proteins (metabolism)
• Child
• Dwarfism (blood, etiology)
• Growth Inhibitors
• Humans
• Hypoglycemia (etiology)
• Insulin-Like Growth Factor Binding Proteins
• Insulin-Like Growth Factor I (analysis, metabolism)
• Insulin-Like Growth Factor II (analysis, metabolism)
• Octreotide (therapeutic use)