Abstract | BACKGROUND: METHODS: RESULTS: Our data suggest that apoprotein B ( apoB)- cysteinylglycine (CysGly), apoB-Hcy, and apoB-Cys concentrations are markedly higher in men than in women. The percentage of CysGly and glutathione on apoB was higher than that of the same thiols in plasma, whereas the other thiols were markedly less prevalent in lipoprotein than in plasma. Pearson correlation showed that among all thiols, only total plasma Hcy is related to apoB-Hcy concentrations. Multiple correlation analysis confirmed that total Hcy was the most important determinant of apoB-Hcy. Age and LDL cholesterol also showed positive associations, but Cys and, mainly, CysGly were negatively associated with apoB-Hcy concentrations. CONCLUSIONS:
apoB-Hcy derivative formation is mainly dependent on total homocysteine concentration. Increased cholesterol concentrations are related to increased apoB-Hcy. CysGly seems to compete with Hcy for binding to LDL apoprotein, suggesting that CysGly may protect against atherosclerosis by decreasing the concentrations of Hcy transferred by LDL from plasma to endothelial and subendothelial spaces.
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Authors | Angelo Zinellu, Elisabetta Zinellu, Salvatore Sotgia, Marilena Formato, Gian Mario Cherchi, Luca Deiana, Ciriaco Carru |
Journal | Clinical chemistry
(Clin Chem)
Vol. 52
Issue 11
Pg. 2054-9
(Nov 2006)
ISSN: 0009-9147 [Print] England |
PMID | 16990421
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoproteins B
- Lipoproteins, LDL
- Sulfhydryl Compounds
- Homocysteine
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Topics |
- Adolescent
- Adult
- Aged
- Apolipoproteins B
(blood, chemistry)
- Female
- Homocysteine
(blood, chemistry)
- Humans
- Lipoproteins, LDL
(blood, chemistry)
- Male
- Middle Aged
- Reference Values
- Risk Factors
- Sex Factors
- Sulfhydryl Compounds
(blood, chemistry)
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