Abstract | PURPOSE: To help resolve the clinical ambiguity between Duane syndrome with severe abduction deficit and abducens palsy, we performed orbital magnetic resonance imaging (MRI) to qualify abnormalities of the lateral rectus (LR) muscle in these entities. DESIGN: Prospective observational case series. METHODS: Orbital MRI was performed in 13 subjects with Duane syndrome (19 eyes), 10 subjects with chronic abducens palsy (10 eyes), and 10 orthotropic control subjects (18 eyes). High-resolution, surface coil, T(1)-weighted MRI was used to obtain contiguous, 2-mm thick quasi-coronal images of the orbits in central gaze. Digital image analysis was used to quantify cross-sectional area of the ipsilesional and contralesional LR to provide comparison with control measurements. RESULTS: Mean maximum LR cross-sectional area in Duane syndrome was statistically similar to control (P = .454) and contralesional LR cross-sectional area (P = .227). However, in chronic abducens palsy, mean maximum ipsilesional LR cross-sectional area was markedly smaller than contralesional (P = .003) and control cross-sectional areas (P < .0001), as well as smaller than the LR in Duane syndrome (P= .0017). CONCLUSIONS:
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Authors | Nam-Yeo Kang, Joseph L Demer |
Journal | American journal of ophthalmology
(Am J Ophthalmol)
Vol. 142
Issue 5
Pg. 827-34
(Nov 2006)
ISSN: 0002-9394 [Print] United States |
PMID | 16989758
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
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Topics |
- Abducens Nerve Diseases
(diagnosis)
- Adolescent
- Adult
- Aged
- Atrophy
- Child
- Child, Preschool
- Chronic Disease
- Duane Retraction Syndrome
(diagnosis)
- Esotropia
(diagnosis)
- Eye Movements
- Female
- Humans
- Magnetic Resonance Imaging
(methods)
- Male
- Middle Aged
- Oculomotor Muscles
(innervation, pathology)
- Orbit
(pathology)
- Prospective Studies
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