Abstract | BACKGROUND: METHOD: Mice were infected intracerebroventricularly with Cryptococcus neoformans 4 h or 5 days prior to a single dose treatment. RESULTS: The brain tissue level and efficacy of AmBisome when administered 5 days after infection were greater than 4 h after infection. An immunohistochemical study showed that AmBisome-derived amphotericin B was localized at the infected site in the subarachnoid space. When AmBisome was compared with Fungizone at the maximum tolerated dose, 10 mg/kg AmBisome exhibited greater efficacy than 1 mg/kg Fungizone in both regimens. CONCLUSION:
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Authors | K Takemoto, Y Yamamoto, Y Ueda |
Journal | Chemotherapy
(Chemotherapy)
Vol. 52
Issue 6
Pg. 271-8
( 2006)
ISSN: 0009-3157 [Print] Switzerland |
PMID | 16988503
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antifungal Agents
- Biomarkers
- liposomal amphotericin B
- Amphotericin B
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Topics |
- Amphotericin B
(administration & dosage, blood, pharmacology)
- Animals
- Antifungal Agents
(administration & dosage, blood, pharmacology)
- Biomarkers
(blood)
- Brain
(drug effects, metabolism, microbiology, pathology)
- Cryptococcus neoformans
(drug effects, isolation & purification)
- Disease Models, Animal
- Disease Progression
- Immunohistochemistry
- Male
- Maximum Tolerated Dose
- Meningitis, Cryptococcal
(drug therapy, microbiology, mortality)
- Mice
- Survival Analysis
- Time Factors
- Treatment Outcome
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