Vasoactive therapies in systemic sclerosis.

Abstract

In systemic sclerosis (SSc), vasculopathy is a central mechanism and is a major initial event in the process of sclerosis and causing different complications such as Raynaud's phenomenon, ulcer(s) or pulmonary hypertension, the latter being life threatening. Therefore, vasoactive therapies are important when taking care of patients with SSc. However, as treatment has been difficult, numerous therapeutic modalities have been suggested. Until now, the interpretation of most studies is limited due to the heterogeneity of patient groups, the low number of patients, the short duration of the treatments and, possibly, further pathogenic mechanisms such as autoimmunity. Several drugs are now available with effects on vasculopathy and, furthermore, on specific pathogenic mechanisms in SSc. Prostacyclins, endothelin receptor antagonists and phosphodiesterase-5 inhibitors have potential effects on fibrosis, inflammation and endothelial cells, suggesting a disease-modifying capacity in systemic sclerosis. This review summarizes evidence-based therapy recommendations.

• Authors: G Riemekasten, C Sunderkötter
• Journal: Rheumatology (Oxford, England) (Rheumatology (Oxford)) Vol. 45 Suppl 3 Pg. iii49-51 (Oct 2006) ISSN: 1462-0324 [Print] England
• PMID: 16987836 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Endothelin Receptor Antagonists
• Phosphodiesterase 5 Inhibitors
• Phosphodiesterase Inhibitors
• Prostaglandins I

Topics

• Endothelin Receptor Antagonists
• Humans
• Phosphodiesterase 5 Inhibitors
• Phosphodiesterase Inhibitors (therapeutic use)
• Prostaglandins I (therapeutic use)
• Scleroderma, Systemic (complications, drug therapy, physiopathology)
• Vascular Diseases (drug therapy, etiology)