[Levonorgestrel-releasing intrauterine system in the treatment of dysfunctional uterine bleeding: A French multicenter study].

Abstract

OBJECTIVE:

To evaluate the levonorgestrel-releasing intra-uterine system as an alternative to surgical treatment in patients presenting with menorrhagia.

PATIENTS AND METHODS:

In the set of a prospective multicenter study, 49 patients with menorrhagia resistant to medical treatment and/or referred for hysterectomy or endometrial ablation were included. Medical visits were organized 3, 6, 12, 24 and 36 months after insertion of the levonorgestrel-releasing intra-uterine system. Visual score of menstrual bleeding and satisfaction index were noted on each visit. Transvaginal ultrasound, pap smear, endometrial biopsy, and clinical data were retrieved one month before and 12 months after inclusion for tolerance evaluation.

RESULTS:

Renouncement rate was 90.0% (95% CI = 80.7-96.6%). After a twelve months follow-up, 86.1% of patients were satisfied or very satisfied with their clinical state. We found a significant increase of hemoglobin rates from baseline (14,0 versus 12,9 g/dl; P < 10(-4)). Similar increases were also found in serum iron and ferritin.

DISCUSSION AND CONCLUSION:

This study confirms the efficacy of the levonorgestrel-releasing intra-uterine system in the control and reduction of menstrual blood loss in patients with dysfunctional uterine bleeding. The high rate of surgery cancellation is a proof of the potential role of the levonorgestrel-releasing intra-uterine system as an alternative treatment in these patients.

• Authors: C Yazbeck, S Omnes, M-C Vacher-Lavenu, P Madelenat
• Journal: Gynecologie, obstetrique & fertilite (Gynecol Obstet Fertil) Vol. 34 Issue 10 Pg. 906-13 (Oct 2006) ISSN: 1297-9589 [Print] France
• Vernacular Title: Efficacité et tolérance du système intra-utérin au lévonorgestrel dans la prise en charge des ménorragies fonctionnelles: étude française multicentrique.
• PMID: 16987684 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)

Chemical References

• Levonorgestrel

Topics

• Adult
• Female
• France
• Humans
• Intrauterine Devices, Medicated
• Levonorgestrel (administration & dosage)
• Menorrhagia (drug therapy, surgery)
• Middle Aged
• Patient Satisfaction
• Prospective Studies
• Treatment Outcome