[Topical tacrolimus and resistant skin lesions of dermatomyositis].

Abstract

INTRODUCTION:

Dermatomyositis is an inflammatory myopathy associated with an increased risk of mortality due to visceral involvement. Cutaneous involvement has no vital impact but considerably affects the quality of life of the patients and can resist to classical therapies. More treatment options are needed. We report here the case of three patients presenting resistant cutaneous lesions of dermatomyositis successfully treated with topical tacrolimus.

OBSERVATIONS:

A dramatic cure of the lesions of the face and the hands and a moderate response of other areas were observed without adverse effects.

CONCLUSION:

Tacrolimus is an immunosuppressive agent and topical tacrolimus is used for the treatment of atopic dermatitis and has been occasionally used to treat skin involvement of some systemic inflammatory diseases. Topical tacrolimus seems to be a good therapeutic alternative for resistant skin lesions of dermatomyositis. It could also be proposed as a first intention therapy because of its good tolerance.

• Authors: I Peyrot, A Sparsa, V Loustaud-Ratti, E Liozon, E Vidal, J-M Bonnetblanc, C Bedane
• Journal: La Revue de medecine interne (Rev Med Interne) Vol. 27 Issue 10 Pg. 730-5 (Oct 2006) ISSN: 0248-8663 [Print] France
• Vernacular Title: Tacrolimus topique et atteintes cutanées résistantes de la dermatomyosite.
• PMID: 16987569 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Immunosuppressive Agents
• Tacrolimus

Topics

• Administration, Cutaneous
• Aged
• Dermatomyositis (drug therapy)
• Female
• Humans
• Immunosuppressive Agents (therapeutic use)
• Male
• Middle Aged
• Tacrolimus (therapeutic use)
• Treatment Outcome