HLA-B locus in Caucasian patients with carbamazepine hypersensitivity.

Abstract

BACKGROUND:

A strong pharmacogenetic association has been reported in Chinese patients between human leukocyte antigen (HLA)-B*1502 and carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS).

METHODS:

We have genotyped the HLA-B alleles in 56 Caucasian patients with varying severities of CBZ hypersensitivity and 43 controls on CBZ without adverse effects.

RESULTS:

None of our patients (including two with blistering skin rashes) were positive for the HLA-B*1502 allele. HLA-B*0702 allele may protect against severe CBZ hypersensitivity but warrants further study. Of secondary interest, the correlation between HLA-B*0801 and HLA-DR3, DQ2 and TNF -308 alleles (on the ancestral haplotype 8.1) is consistent with our previous findings.

CONCLUSION:

HLA-B*1502 does not seem to be a marker for all forms of CBZ-induced hypersensitivity in a Caucasian population.

• Authors: Ana Alfirevic, Andrea L Jorgensen, Paula R Williamson, David W Chadwick, B Kevin Park, Munir Pirmohamed
• Journal: Pharmacogenomics (Pharmacogenomics) Vol. 7 Issue 6 Pg. 813-8 (Sep 2006) ISSN: 1462-2416 [Print] England
• PMID: 16981842 (Publication Type: Journal Article)

Chemical References

• Genetic Markers
• HLA-B Antigens
• HLA-B*07:02 antigen
• HLA-B*08:01 antigen
• HLA-B*15:02 antigen
• HLA-B15 Antigen
• HLA-B7 Antigen
• HLA-B8 Antigen
• HLA-DQ Antigens
• HLA-DQ2 antigen
• HLA-DR3 Antigen
• Carbamazepine

Topics

• Alleles
• Asian People (genetics)
• Carbamazepine (adverse effects)
• Case-Control Studies
• Drug Hypersensitivity (genetics, immunology)
• Gene Frequency
• Genetic Markers
• HLA-B Antigens (genetics)
• HLA-B15 Antigen
• HLA-B7 Antigen
• HLA-B8 Antigen
• HLA-DQ Antigens (genetics)
• HLA-DR3 Antigen (genetics)
• Humans
• Toxicogenetics
• United Kingdom
• White People (genetics)