New dihydrodibenzoxepins from Bulbophyllum kwangtungense.

Abstract

Three new dihydrodibenzoxepins 7,8-dihydro-5-hydroxy-12,13-methylenedioxy-11-methoxyldibenz[ B,F]oxepin (1), 7,8-dihydro-4-hydroxy-12,13-methylenedioxy-11-methoxyldibenz[ B,F]oxepin (2), and 7,8-dihydro-3-hydroxy-12,13-methylenedioxy-11-methoxyldibenz[ B,F]oxepin (3), were isolated from Bulbophyllum kwangtungense Schlecht, along with three known compounds, cumulatin (4), densiflorol A (5) and plicatol B (6). Their structures were established by a combination of 1D and 2D NMR spectroscopic techniques. All new compounds (1-3) and the known compound densiflorol A (5) exhibited anti-tumor activities against HeLa and K562 human tumor cell lines.

• Authors: Bin Wu, Shan He, Yuan-jiang Pan
• Journal: Planta medica (Planta Med) Vol. 72 Issue 13 Pg. 1244-7 (Oct 2006) ISSN: 0032-0943 [Print] Germany
• PMID: 16981129 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Dibenzoxepins

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Cell Line, Tumor
• Dibenzoxepins (chemistry, isolation & purification, pharmacology)
• Humans
• Molecular Conformation
• Nuclear Magnetic Resonance, Biomolecular
• Orchidaceae (chemistry)