Abstract | BACKGROUND: Previous studies on the efficacy of primary treatments for ductal carcinoma-in-situ ( DCIS) have focused on local recurrence rates. Our objective was to detail the outcomes of local invasive recurrence, distant recurrence, and breast cancer mortality in patients previously treated for DCIS. METHODS: Clinical, pathologic, and outcome data were collected prospectively for 1236 patients with pure DCIS accrued from 1972 through 2005. RESULTS: There were 150 recurrences (87 DCIS and 63 invasive). Invasive local recurrence after mastectomy was rare (0.5% of patients) and after breast preservation was more frequent (12.0% of patients). The 12-year probabilities of breast cancer-specific mortality after mastectomy and after breast preservation were 0.8% and 1.0%, respectively. The 12-year breast cancer-specific mortality and distant disease probability for the 63 patients with invasive recurrences were 12% and 15%, respectively. CONCLUSIONS: Regardless of initial treatment, most patients with invasive local recurrence after treatment for DCIS can be treated and cured.
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Authors | Laura A Lee, Melvin J Silverstein, Cathie T Chung, Heather Macdonald, Premal Sanghavi, Melinda Epstein, Dennis R Holmes, Howard Silberman, Wei Ye, Michael D Lagios |
Journal | American journal of surgery
(Am J Surg)
Vol. 192
Issue 4
Pg. 416-9
(Oct 2006)
ISSN: 0002-9610 [Print] United States |
PMID | 16978940
(Publication Type: Journal Article)
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Topics |
- Breast Neoplasms
(mortality, pathology, surgery)
- Carcinoma, Intraductal, Noninfiltrating
(mortality, secondary, surgery)
- Disease-Free Survival
- Female
- Follow-Up Studies
- Humans
- Mastectomy
- Neoplasm Invasiveness
- Neoplasm Recurrence, Local
(mortality, pathology, surgery)
- Prospective Studies
- Survival Rate
- Treatment Outcome
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