Radiation-induced brain tumours in nevoid basal cell carcinoma syndrome: implications for treatment and surveillance.

Abstract

INTRODUCTION:

We report two cases of radiation-induced intracranial tumours after treatment for medulloblastoma presenting in children with nevoid basal cell carcinoma syndrome.

DISCUSSION:

These cases illustrate the need for judicious use of post-operative radiotherapy as secondary tumors are commonly reported. This is particularly important as the initial tumour in this cohort is of the 'less aggressive' desmoplastic subtype.

• Authors: Q Choudry, H C Patel, N T Gurusinghe, D G Evans
• Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (Childs Nerv Syst) Vol. 23 Issue 1 Pg. 133-6 (Jan 2007) ISSN: 0256-7040 [Print] Germany
• PMID: 16977487 (Publication Type: Case Reports, Journal Article)

Topics

• Adolescent
• Adult
• Astrocytoma (etiology)
• Basal Cell Nevus Syndrome (complications, genetics, physiopathology)
• Brain Neoplasms (etiology)
• Cerebellar Neoplasms (etiology, radiotherapy)
• Female
• Humans
• Infant
• Male
• Medulloblastoma (etiology, radiotherapy)
• Neoplasms, Radiation-Induced
• Radiotherapy (adverse effects)