Abstract | OBJECTIVE: SETTING: Paediatric intensive care unit (PICU). DESIGN: Audit of clinical experience. SUBJECTS: INTERVENTIONS: Algorithm-driven administration of intravenous midazolam to control RSE. Regular, mandatory, patient evaluation to avoid delay in the appropriate escalation of therapy. Our target was the abolition of clinical seizures within 30 min of initiating treatment and early confirmation of cessation of all seizure activity using EEG. The algorithm had failed if clinical seizures persisted beyond 30 min despite the administration of midazolam at 24 microg/kg/min or if administration of a further acute anti-epileptic drug was required to achieve seizure control. MEASUREMENTS: The midazolam infusion rate, cumulative midazolam dose and duration of midazolam therapy at time of clinical seizure control were recorded. Haemodynamic parameters were recorded continuously. Episodes of algorithm failure, breakthrough seizures and seizure relapses were identified. Patient outcome was measured in terms of survival to PICU discharge. RESULTS: In 13 patients (76%) midazolam achieved clinical seizure control within 30 min of treatment initiation. Midazolam was eventually successful in treating 15 seizure episodes (88%). Breakthrough seizures occurred in 8 patients (47%). Relapse after discontinuation of therapy occurred in 1 patient (6%). No significant adverse effects attributable to the use of midazolam occurred. There were 3 deaths (18%) related to underlying CNS pathology. CONCLUSIONS:
|
Authors | Gavin Morrison, Elizabeth Gibbons, William Patrick Whitehouse |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 32
Issue 12
Pg. 2070-6
(Dec 2006)
ISSN: 0342-4642 [Print] United States |
PMID | 16977485
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
- Anticonvulsants
- Hypnotics and Sedatives
- Midazolam
|
Topics |
- Adolescent
- Algorithms
- Anticonvulsants
(therapeutic use)
- Child
- Child, Preschool
- Dose-Response Relationship, Drug
- Electroencephalography
- Humans
- Hypnotics and Sedatives
(administration & dosage, therapeutic use)
- Infant
- Infusions, Intravenous
- Intensive Care Units, Pediatric
- Midazolam
(administration & dosage, therapeutic use)
- Status Epilepticus
(drug therapy, mortality)
- Time Factors
|