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Solar simulator-induced phototoxicity of the furoquinoline alkaloid dictamnine compared to 8-methoxypsoralen and 5-methoxypsoralen.

Abstract
Dictamnine, a furoquinoline alkaloid of the Rutaceae plant family, has been shown to be mutagenic and phototoxic in bacteria and yeasts. Here, we have investigated the phototoxic effect of dictamnine in human Jurkat T cells and HaCaT keratinocytes. Dictamnine was isolated from the roots of DICTAMNUS ALBA L. and was photoactivated with solar simulated radiation, delivered from a 1000-W xenon arc lamp with a maximal output between 300 - 800 nm. Dictamnine displayed concentration- and light-dependent phototoxic effects in both cell lines. In comparison to the structurally related furocoumarins 5-methoxypsoralen and 8-methoxypsoralen, dictamnine was less phototoxic. Nevertheless, it may play a major role in the elicitation of phytophotodermatitis because of its abundance in plants of the Rutaceae family.
AuthorsChristoph M Schempp, Birgit Simon-Haarhaus, Richard Krieger, Jan C Simon
JournalPlanta medica (Planta Med) Vol. 72 Issue 10 Pg. 941-3 (Aug 2006) ISSN: 0032-0943 [Print] Germany
PMID16972199 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Quinolines
  • 5-Methoxypsoralen
  • dictamnine
  • Methoxsalen
Topics
  • 5-Methoxypsoralen
  • Cell Line, Tumor
  • Cell Proliferation (drug effects, radiation effects)
  • Dictamnus (chemistry)
  • Humans
  • Keratinocytes (drug effects, radiation effects)
  • Methoxsalen (analogs & derivatives, chemistry, toxicity)
  • Plant Roots (chemistry)
  • Quinolines (chemistry, isolation & purification, toxicity)
  • Ultraviolet Rays

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