Abstract |
FDG PET can detect thyroid cancer in patients referred for exploration of a different cancer. Because of its lack of specificity, however, this modality is not indicated for examination of thyroid nodules: ultrasonography and fine needle biopsy with cytology allow histological diagnosis, which can be completed by iodine-123 scintigraphy when an autonomous nodule is suspected. No information is currently available about the utility of FDG PET in preoperative staging. In follow-up of patients undergoing thyroidectomy for adenocarcinoma, FDG PET is useful for detecting recurrence in cases where serum thyroglobulin levels rise and iodine-131 scintigraphy is negative: surgical resection may be appropriate. Nonetheless FDG PET should be performed more widely and earlier: the initial presence of foci positive for FDG is a major predictor of shorter survival, and most cancer lesions take up either iodine or FDG. In follow-up of medullary carcinoma, FDG PET detects residual tissue better than any other scintigraphic procedures, especially when serum levels of CEA ( carcinoembryonic antigen) are rising rapidly. FDOPA PET seems to have better sensitivity than FDG-PET and may be useful in occult recurrence, as three case reports indicate.
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Authors | Jean-Noël Talbot, Françoise Montravers, Nassima Younsi, Paolo Zanotti-Fregonara, Paolo Zanotti, Dany Grahek, Khaldoun Kerrou, Fabrice Gutman, Sophie Périé, Gérard Maurel, Jean Lacau Saint Guily, Jean-Yves Devaux, Françoise Duron |
Journal | Presse medicale (Paris, France : 1983)
(Presse Med)
Vol. 35
Issue 9 Pt 2
Pg. 1377-85
(Sep 2006)
ISSN: 0755-4982 [Print] France |
Vernacular Title | La TEP dans le cancer de la glande thyroïde. |
PMID | 16969334
(Publication Type: Journal Article, Review)
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Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
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Topics |
- Adenocarcinoma
(diagnostic imaging, surgery)
- Carcinoma, Medullary
(diagnostic imaging)
- Fluorodeoxyglucose F18
- Humans
- Positron-Emission Tomography
- Radiopharmaceuticals
- Thyroid Neoplasms
(diagnostic imaging, surgery)
- Thyroidectomy
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