HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

[The progress of hepatic arterial infusion chemotherapy for hepatocellular carcinoma]

AbstractHepatic arterial infusion (HAI) chemotherapy has been selected as a therapeutic option for highly advanced hepatocellular carcinoma (HCC) with tumor thrombi in major portal branches or intrahepatic metastases. Conventional therapies have no clinical effect on highly advanced HCC. Recent advances of an implanted portcatheter system have facilitated repeated arterial infusion of chemotherapeutic agents, and HAI chemotherapy with several anticancer drugs provides a useful choice for advanced HCC. In various regimens of HAI chemotherapy, low-dose cisplatin and 5-fluorouracil (5-FU) therapy or combination therapy of interferon (IFN)-alpha/5-FU have been reported to improve the response rates for advanced HCC. However, the survival benefit of HAI chemotherapy may be affected by liver function. None of these regimens have been proved to be the standard for HAI chemotherapy. We previously reported that the beneficial effects of combination therapy of IFN-alpha/5-FU for advanced HCC. IFN-alpha/5-FU combination therapy may be a promising treatment modality for advanced HCC.
AuthorsTakehiro Noda, Hiroaki Nagano, Hiroshi Wada, Shigeru Marubashi, Atsushi Miyamoto, Yutaka Takeda, Koji Umeshita, Keizo Dono, Keigo Ohsuga, Tonsok Kim, Kaname Tomoda, Hironobu Nakamura, Morito Monden (Affiliation: Dept. of Surgery, Graduate School of Medicine, Osaka University.)
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 33 Issue 9 Pg. 1221-5 (Sep 2006) ISSN: 0385-0684 [Print] Japan
PMID16969014 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • CF regimen
  • Interferon-alpha
  • Cisplatin
  • Fluorouracil
Topics
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
  • Carcinoma, Hepatocellular (drug therapy)
  • Cisplatin (administration & dosage)
  • Drug Administration Schedule
  • Fluorouracil (administration & dosage)
  • Hepatic Artery
  • Humans
  • Infusions, Intra-Arterial
  • Interferon-alpha (administration & dosage)
  • Liver Neoplasms (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password:


Research Interface PRO additionally includes drill-down to evidence, articles by author, export to Excel, FDA Link and mobile subscription:
1 year subscription, $45.00 USD