Natriuretic peptides in the diagnosis and management of heart failure.

Abstract

The natriuretic peptides are a family of related hormones that play a crucial role in cardiovascular homeostasis. They have recently emerged as potentially important clinical markers in heart failure. Recent data have suggested an important role for these markers in establishing the diagnosis of heart failure in patients with unexplained dyspnea in both acute care and ambulatory settings. Other clinical uses of the natriuretic peptides, such as screening for asymptomatic ventricular dysfunction, establishing prognosis or guiding titration of drug therapy, are under investigation but have not yet sufficiently been validated for widespread clinical use.

• Authors: G Michael Felker, John W Petersen, Daniel B Mark
• Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne (CMAJ) Vol. 175 Issue 6 Pg. 611-7 (Sep 12 2006) ISSN: 1488-2329 [Electronic] Canada
• PMID: 16966666 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers
• Peptide Fragments
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain
• Atrial Natriuretic Factor

Topics

• Atrial Natriuretic Factor (blood, physiology)
• Bayes Theorem
• Biomarkers (blood)
• Dyspnea (blood, etiology)
• Heart Failure (complications, diagnosis, physiopathology)
• Humans
• Likelihood Functions
• Natriuretic Peptide, Brain (blood, physiology)
• Peptide Fragments (blood)
• Prognosis
• ROC Curve
• Reference Values
• Sensitivity and Specificity
• Treatment Outcome
• Ventricular Dysfunction, Left (diagnosis)