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Necrobiotic xanthogranuloma treated with chlorambucil.

Abstract
We report a case of necrobiotic xanthogranuloma that responded to treatment with chlorambucil. A 56-year-old man presented with a 5-year history of multiple, mildly pruritic, brown-to-violaceous plaques with central ulceration and atrophy involving the periorbital area, extremities, and trunk. Laboratory studies showed mild leukopenia and a monoclonal gammopathy of the IgG lambda type on serum protein immunoelectrophoresis. Histopathological evaluation revealed a dense histiocytic infiltrate with hyaline necrobiosis involving the dermis with extension to the subcutis. Multiple large multinucleated giant cells and scattered lymphocytes were seen. A diagnosis of necrobiotic xanthogranuloma was established. The patient was started on chlorambucil initially at 2 mg per day. The dose was later increased to 4 mg per day, which resulted in flattening and complete resolution of his skin lesions.
AuthorsSima Z Torabian, Nasim Fazel, Robin Knuttle
JournalDermatology online journal (Dermatol Online J) Vol. 12 Issue 5 Pg. 11 (Sep 08 2006) ISSN: 1087-2108 [Electronic] United States
PMID16962026 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antineoplastic Agents, Alkylating
  • Chlorambucil
Topics
  • Antineoplastic Agents, Alkylating (therapeutic use)
  • Chlorambucil (therapeutic use)
  • Dose-Response Relationship, Drug
  • Granuloma (drug therapy, pathology)
  • Humans
  • Male
  • Middle Aged
  • Xanthomatosis (drug therapy, pathology)

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