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Successful treatment of intractable hemothorax with recombinant factor VIIa in a nonhemophilic patient.

Abstract
Recombinant factor VIIa (rFVIIa) was developed for the treatment of bleeding in hemophilic patients with inhibitors. It has also been used to stop bleeding in nonhemophilic patients who fail to respond to conventional treatment. We report a case of catastrophic hemothorax in which bleeding was stopped by administration of rFVIIa. A 68-year-old woman with chronic hepatitis C-related liver cirrhosis was admitted due to pneumonia and parapneumonic effusion. The patient developed hemothorax and hypovolemic shock after thoracentesis. Conventional therapies including tube thoracostomy and transarterial embolization failed to stop the life-threatening bleeding. The bleeding stopped after administration of rFVIIa 100 microg/kg/BW at 2-hour intervals for a total of two doses on the 3rd day of hospitalization. Despite intensive care, however, the patient died due to nosocomial infection and multiple organ failure on the 12th day of hospitalization. Hemothorax in a nonhemophilic patient can be successfully treated with rFVIIa.
AuthorsYu-Feng Wei, Chao-Chi Ho, Ming-Tzer Lin, Ang Yuan, Chong-Jen Yu
JournalJournal of the Formosan Medical Association = Taiwan yi zhi (J Formos Med Assoc) Vol. 105 Issue 9 Pg. 765-9 (Sep 2006) ISSN: 0929-6646 [Print] Singapore
PMID16959626 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Recombinant Proteins
  • Factor VII
  • recombinant FVIIa
  • Factor VIIa
Topics
  • Aged
  • Chronic Disease
  • Drug Administration Schedule
  • Factor VII (administration & dosage)
  • Factor VIIa
  • Female
  • Hemothorax (drug therapy)
  • Hepatitis C (complications)
  • Humans
  • Liver Cirrhosis (etiology)
  • Recombinant Proteins (administration & dosage)

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