Abstract | BACKGROUND: AIM: To ascertain the genetic and immunological risk factors for CIA, and on the basis of these findings to construct an explanatory model for CIA. METHOD: We reviewed the literature via Medline (from 1966 to May 2004) and EMBASE (from 1980 to May 2004) using the search terms ' clozapine' and ' agranulocytosis'. RESULTS: CONCLUSION: It seems likely that CIA can be explained on the basis of genetic and immunotoxic factors. The model should help us to understand how agranulocytosis can be caused by various antipsychotics and how it can be treated. However, it is not yet possible to identify patients who are particularly at risk for CIA.
|
Authors | Y Güzelcan, W F Scholte |
Journal | Tijdschrift voor psychiatrie
(Tijdschr Psychiatr)
Vol. 48
Issue 4
Pg. 295-302
( 2006)
ISSN: 0303-7339 [Print] Netherlands |
Vernacular Title | Door clozapine geïnduceerde agranulocytose: genetische en immunologische verklaringen. |
PMID | 16955993
(Publication Type: English Abstract, Journal Article, Meta-Analysis, Review)
|
Chemical References |
- Antipsychotic Agents
- HLA Antigens
- Clozapine
|
Topics |
- Agranulocytosis
(chemically induced, genetics)
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Clozapine
(adverse effects, therapeutic use)
- Genetic Predisposition to Disease
- HLA Antigens
(genetics)
- Humans
- Major Histocompatibility Complex
(genetics)
- Risk Factors
- Schizophrenia
(drug therapy)
|