Abstract | BACKGROUND: OBJECTIVES: METHODS: Rates of ambulatory visits for pneumococcal and nonspecific pneumonia, otitis media, and other acute respiratory infections were compared before (1994-1999) and after (2002-2003) heptavalent pneumococcal conjugate vaccine introduction using the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey. To evaluate vaccine effects while accounting for temporal variability, ratios of pneumococcal-related disease rates in children < 2 years old ( vaccine target population) and in children 3 to 6 years old (not routinely vaccinated) were evaluated using a Poisson regression analysis. For children < 2 years old, the differences between observed and expected rates were the estimated vaccine effects. RESULTS: CONCLUSIONS:
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Authors | Carlos G Grijalva, Katherine A Poehling, J Pekka Nuorti, Yuwei Zhu, Stacey W Martin, Kathryn M Edwards, Marie R Griffin |
Journal | Pediatrics
(Pediatrics)
Vol. 118
Issue 3
Pg. 865-73
(Sep 2006)
ISSN: 1098-4275 [Electronic] United States |
PMID | 16950975
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Pneumococcal Vaccines
- Vaccines, Conjugate
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Topics |
- Ambulatory Care
(statistics & numerical data)
- Child
- Child, Preschool
- Female
- Humans
- Immunization Programs
- Infant
- Infant, Newborn
- Male
- Otitis Media
(microbiology, prevention & control, therapy)
- Outpatients
- Pneumococcal Infections
(mortality, prevention & control, therapy)
- Pneumococcal Vaccines
- Retrospective Studies
- United States
(epidemiology)
- Vaccines, Conjugate
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