Synthesis of radiolabeled stilbene derivatives as new potential PET probes for aryl hydrocarbon receptor in cancers.

Abstract

New carbon-11 and fluorine-18 labeled stilbene derivatives, cis-3,5-dimethoxy-4'-[11C]methoxystilbene (4'-[11C]8a), cis-3,4',5-trimethoxy-3'-[11C]methoxystilbene (3'-[11C]8b), trans-3,5-dimethoxy-4'-[11C]methoxystilbene (4'-[11C]10a), trans-3,4',5-trimethoxy-3'-[11C]methoxystilbene (3'-[11C]10b), cis-3,5-dimethoxy-4'-[18F]fluorostilbene (4'-[18F]12a), and trans-3,5-dimethoxy-4'-[18F]fluorostilbene (4'-[18F]13a), were designed and synthesized as potential PET probes for aryl hydrocarbon receptor (AhR) in cancers.

• Authors: Mingzhang Gao, Min Wang, Kathy D Miller, George W Sledge, Gary D Hutchins, Qi-Huang Zheng
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 16 Issue 22 Pg. 5767-72 (Nov 15 2006) ISSN: 0960-894X [Print] England
• PMID: 16950622 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Carbon Radioisotopes
• Fluorine Radioisotopes
• Radiopharmaceuticals
• Receptors, Aryl Hydrocarbon
• Stilbenes

Topics

• Animals
• Carbon Radioisotopes
• Fluorine Radioisotopes
• Models, Chemical
• Neoplasms (diagnosis)
• Radiopharmaceuticals (chemical synthesis)
• Rats
• Receptors, Aryl Hydrocarbon (metabolism)
• Stereoisomerism
• Stilbenes (chemical synthesis)
• Tomography, Emission-Computed (methods)