In vitro activities of ertapenem against drug-resistant Streptococcus pneumoniae and other respiratory pathogens from 12 Asian countries.

Abstract

In vitro activities of ertapenem and 11 other comparator agents were tested against 1025 isolates of respiratory pathogens collected from 12 Asian countries. Resistance rate to ertapenem was 1.2% in 602 isolates of Streptococcus pneumoniae (MIC(50), 0.06/MIC(90), 1 microg/mL). Ertapenem was also very active against penicillin-, ciprofloxacin-, erythromycin-, and multidrug-resistant pneumococcal isolates (resistance rate: 3.5%, 2.7%, 1.9%, and 2.7%, respectively). Ertapenem-resistant pneumococcal isolates were found only in Vietnam and Korea. Ertapenem resistance was not found in methicillin-susceptible Staphylococcus aureus, Haemophilus influenzae, Moraxella catarrhalis, and Klebsiella pneumoniae, including extended-spectrum beta-lactamase producers. In vitro data suggest that ertapenem could be a useful treatment option for community-acquired pneumonia.

• Authors: Jae-Hoon Song, Kwan Soo Ko, Mi Young Lee, Sulhee Park, Jin Yang Baek, Ji-Young Lee, Sang Taek Heo, Ki Tae Kwon, Seong Yeol Ryu, Won Sup Oh, Kyong Ran Peck, Nam Yong Lee
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) Vol. 56 Issue 4 Pg. 445-50 (Dec 2006) ISSN: 0732-8893 [Print] United States
• PMID: 16949783 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• beta-Lactams
• beta-Lactamases
• Ertapenem

Topics

• Anti-Bacterial Agents (pharmacology)
• Asia (epidemiology)
• Bacterial Infections (epidemiology, microbiology)
• Drug Resistance, Multiple, Bacterial
• Ertapenem
• Gram-Negative Bacteria (drug effects, enzymology)
• Gram-Negative Bacterial Infections (epidemiology, microbiology)
• Humans
• Microbial Sensitivity Tests
• Pneumococcal Infections (epidemiology, microbiology)
• Respiratory Tract Infections (epidemiology, microbiology)
• Sentinel Surveillance
• Streptococcus pneumoniae (drug effects)
• beta-Lactamases (biosynthesis)
• beta-Lactams (pharmacology)