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Selective induction of prostate carcinomas in F344 rats treated with intraperitoneal injections of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl.

Abstract
Groups of F344 and Wistar rats were given an intraperitoneal injection of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl (N-OH-DMAB) at a dose of 5 mg/kg body weight with a 1-week dietary pretreatment with ethinyl estradiol (EE), and this regimen was repeated 10 times at one-week intervals. Additional groups were given N-OH-DMAB 10 times without the dietary EE pretreatment. The total experimental period was 60 weeks. Carcinomas and atypical hyperplasias of the prostate developed in 8 (42%) and 16 (84%) of 19 F344 rats without the dietary EE treatment and in 1 (6%) and 7 (39%) of 18 rats with the EE diet, respectively. No prostatic tumors were found in Wistar rats, although atypical hyperplasias were observed in 6 of 18 rats with and 4 of 8 rats without the EE supplementation. Tumor yields in other organs were extremely low, resulting in good survival of the animals. A comparison of the results with those obtained for DMAB suggests that intraperitoneal administration of N-OH-DMAB in F344 provides a better induction method for models of prostate carcinogenesis.
AuthorsT Shirai, A Nakamura, S Fukushima, C Y Wang, H Yamada, N Ito
JournalJapanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 81 Issue 4 Pg. 320-3 (Apr 1990) ISSN: 0910-5050 [Print] Japan
PMID1694839 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Aminobiphenyl Compounds
  • Carcinogens
  • N-hydroxy-3,2'-dimethyl-4-aminobiphenyl
Topics
  • Aminobiphenyl Compounds (administration & dosage, toxicity)
  • Animals
  • Body Weight (drug effects)
  • Carcinogens (administration & dosage, toxicity)
  • Injections, Intraperitoneal
  • Male
  • Prostatic Hyperplasia (pathology)
  • Prostatic Neoplasms (chemically induced)
  • Rats
  • Rats, Inbred F344
  • Rats, Inbred Strains

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