Abstract |
Groups of F344 and Wistar rats were given an intraperitoneal injection of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl (N- OH-DMAB) at a dose of 5 mg/kg body weight with a 1-week dietary pretreatment with ethinyl estradiol (EE), and this regimen was repeated 10 times at one-week intervals. Additional groups were given N- OH-DMAB 10 times without the dietary EE pretreatment. The total experimental period was 60 weeks. Carcinomas and atypical hyperplasias of the prostate developed in 8 (42%) and 16 (84%) of 19 F344 rats without the dietary EE treatment and in 1 (6%) and 7 (39%) of 18 rats with the EE diet, respectively. No prostatic tumors were found in Wistar rats, although atypical hyperplasias were observed in 6 of 18 rats with and 4 of 8 rats without the EE supplementation. Tumor yields in other organs were extremely low, resulting in good survival of the animals. A comparison of the results with those obtained for DMAB suggests that intraperitoneal administration of N- OH-DMAB in F344 provides a better induction method for models of prostate carcinogenesis.
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Authors | T Shirai, A Nakamura, S Fukushima, C Y Wang, H Yamada, N Ito |
Journal | Japanese journal of cancer research : Gann
(Jpn J Cancer Res)
Vol. 81
Issue 4
Pg. 320-3
(Apr 1990)
ISSN: 0910-5050 [Print] Japan |
PMID | 1694839
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Aminobiphenyl Compounds
- Carcinogens
- N-hydroxy-3,2'-dimethyl-4-aminobiphenyl
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Topics |
- Aminobiphenyl Compounds
(administration & dosage, toxicity)
- Animals
- Body Weight
(drug effects)
- Carcinogens
(administration & dosage, toxicity)
- Injections, Intraperitoneal
- Male
- Prostatic Hyperplasia
(pathology)
- Prostatic Neoplasms
(chemically induced)
- Rats
- Rats, Inbred F344
- Rats, Inbred Strains
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