Abstract | BACKGROUND: PATIENTS: The carnitine levels of 19 patients aged 1.4 to 8.5 years (median 4.0 years), who were treated with ketogenic diet because of pharmacoresistent epilepsy, were evaluated retrospectively. RESULTS:
Carnitine deficiency during KD was detected in 26 % of the patients and in 57 % of the patients without carnitine substitution. Decreased carnitine level occurred also with carnitine substitution independent from additional valproat therapy. The time of appearance of carnitine deficiency on KD was between 3 days and 248 weeks (median 32 weeks). CONCLUSION:
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Authors | G Liebhaber, B Pascher, K Gempel, F A Baumeister |
Journal | Klinische Padiatrie
(Klin Padiatr)
2006 Sep-Oct
Vol. 218
Issue 5
Pg. 260-3
ISSN: 0300-8630 [Print] Germany |
Vernacular Title | Asymptomatischer Carnitinmangel unter ketogener Diät bei Patienten mit pharmakoresistenten Epilepsien. |
PMID | 16947093
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anticonvulsants
- Dietary Carbohydrates
- Dietary Fats
- Ketone Bodies
- acylcarnitine
- Valproic Acid
- Carnitine
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Topics |
- Anticonvulsants
(administration & dosage)
- Carnitine
(administration & dosage, analogs & derivatives, blood, deficiency)
- Child, Preschool
- Combined Modality Therapy
- Dietary Carbohydrates
(administration & dosage)
- Dietary Fats
(administration & dosage)
- Drug Resistance
- Epilepsy
(blood, diet therapy)
- Female
- Humans
- Infant
- Infant, Newborn
- Ketone Bodies
(blood)
- Male
- Treatment Outcome
- Valproic Acid
(administration & dosage)
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