Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis.

Abstract

In our previous efforts to find new tyrosinase inhibitory materials, we investigated 44 Indonesian medicinal plants belonging to 24 families. Among those plants, the extract of Artocarpus heterophyllus was one of the strongest inhibitors of tyrosinase activity. By activity-guided fractionation of A. heterophyllus wood extract, we isolated artocarpanone, which inhibited both mushroom tyrosinase activity and melanin production in B16 melanoma cells. This compound is a strong candidate as a remedy for hyperpigmentation in human skin.

• Authors: Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro Kondo
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 29 Issue 9 Pg. 1966-9 (Sep 2006) ISSN: 0918-6158 [Print] Japan
• PMID: 16946519 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Enzyme Inhibitors
• Flavones
• Melanins
• Plant Extracts
• artocarpanone
• Monophenol Monooxygenase

Topics

• Agaricales (enzymology)
• Animals
• Antioxidants (pharmacology)
• Artocarpus (chemistry)
• Cell Line, Tumor
• Enzyme Inhibitors (pharmacology)
• Flavones (pharmacology)
• Melanins (biosynthesis)
• Melanoma, Experimental (metabolism)
• Mice
• Monophenol Monooxygenase (antagonists & inhibitors)
• Plant Extracts (pharmacology)