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Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.

Abstract
A 66-year-old pseudophakic man with primary open-angle glaucoma and ocular cicatricial pemphigoid underwent trabeculectomy and was given postoperative subconjunctival 5-fluorouracil. He developed an inferior corneal epithelial defect and, later, a well-demarcated area of inferior corneal keratinization. Since the corneal keratinization clinically improved with conservative management, surgical intervention was not required.
AuthorsM J Phelan, G L Skuta
JournalOphthalmic surgery (Ophthalmic Surg) Vol. 21 Issue 4 Pg. 296-8 (Apr 1990) ISSN: 0022-023X [Print] United States
PMID1694575 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Ointments
  • Keratins
  • Fluorouracil
Topics
  • Aged
  • Conjunctiva (metabolism)
  • Corneal Diseases (drug therapy, etiology)
  • Fluorouracil (adverse effects)
  • Glaucoma, Open-Angle (complications, drug therapy, surgery)
  • Humans
  • Intraocular Pressure
  • Keratins
  • Male
  • Ointments (therapeutic use)
  • Pemphigoid, Benign Mucous Membrane (complications, diagnosis)
  • Reoperation
  • Trabeculectomy (adverse effects)

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