Endothelial monocyte-activating polypeptide-II and its functions in (patho)physiological processes.

Abstract	Endothelial monocyte-activating polypeptide-II (EMAP-II) is a pro-inflammatory cytokine with anti-angiogenic properties. Its precursor, proEMAP, is identical to the p43 auxiliary component of the tRNA multisynthetase complex and therefore involved in protein translation. Although most of the activities have been ascribed to the active form EMAP-II, also p43 has reported cytokine properties. ProEMAP/p43 and EMAP-II act on many levels and on many cell types including endothelial cells, immune cells and fibroblasts. In this review we summarize all available data on isolation, expression and functions of EMAP-II both in physiological processes as well as in pathological settings, like cancer. We also discuss the different reported mechanisms for processing of proEMAP/p43 into EMAP-II. Finally, we speculate on the possible applications of this cytokine for (cancer) therapy.
Authors	Remco van Horssen, Alexander M M Eggermont, Timo L M ten Hagen
Journal	Cytokine & growth factor reviews (Cytokine Growth Factor Rev) Vol. 17 Issue 5 Pg. 339-48 (Oct 2006) ISSN: 1359-6101 [Print] England
PMID	16945568 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	Angiogenesis Inhibitors Antineoplastic Agents Cytokines Inflammation Mediators Neoplasm Proteins Protein Precursors RNA-Binding Proteins small inducible cytokine subfamily E, member 1
Topics	Amino Acid Sequence Angiogenesis Inhibitors (therapeutic use) Animals Antineoplastic Agents (therapeutic use) Apoptosis Base Sequence Cytokines (biosynthesis, isolation & purification, physiology, therapeutic use) Humans Inflammation (physiopathology) Inflammation Mediators Molecular Sequence Data Neoplasm Proteins (biosynthesis, isolation & purification, physiology, therapeutic use) Protein Precursors Protein Structure, Tertiary RNA-Binding Proteins (biosynthesis, isolation & purification, physiology, therapeutic use) Sequence Homology, Amino Acid

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