HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Induction of monocarboxylate transporter 2 expression and ketone transport following traumatic brain injury in juvenile and adult rats.

Abstract
Based on recent work demonstrating age-dependent ketogenic neuroprotection after traumatic brain injury (TBI), it was hypothesized that the neuroprotection among early post-weaned animals was related to induced cerebral transport of ketones after injury. Regional changes in monocarboxylate transporter 2 (MCT2) were acutely examined with immunohistochemistry after sham surgery or controlled cortical impact injury among postnatal day 35 and adult rats. Both ages showed elevated MCT2 expression in the ipsilateral cerebral vasculature after TBI. Using Western blotting, MCT2 expression was 80-88% greater in microvessels isolated from postnatal day 35 rats at all time points relative to adults. The increased MCT2 expression was temporally correlated with an age-related increase in cerebral uptake of ketones, when ketones were made available after injury.
AuthorsM L Prins, C C Giza
JournalDevelopmental neuroscience (Dev Neurosci) Vol. 28 Issue 4-5 Pg. 447-56 ( 2006) ISSN: 0378-5866 [Print] Switzerland
PMID16943667 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
CopyrightCopyright (c) 2006 S. Karger AG, Basel.
Chemical References
  • Ketones
  • Monocarboxylic Acid Transporters
  • Slc16a7 protein, rat
Topics
  • Aging (physiology)
  • Animals
  • Blood-Brain Barrier (cytology, metabolism)
  • Brain (growth & development, metabolism, physiopathology)
  • Brain Injuries (metabolism, physiopathology)
  • Cerebral Arteries (metabolism)
  • Cerebral Cortex (growth & development, metabolism, physiopathology)
  • Cytoprotection (physiology)
  • Disease Models, Animal
  • Hippocampus (growth & development, metabolism, physiopathology)
  • Immunohistochemistry
  • Ketones (metabolism)
  • Male
  • Microcirculation (metabolism)
  • Monocarboxylic Acid Transporters (metabolism)
  • Rats
  • Rats, Sprague-Dawley
  • Recovery of Function (physiology)
  • Up-Regulation (physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: