Duodenal SP-like immunoreactivity is decreased in experimentally-induced duodenal ulcers.

Abstract	Substance P-like immunoreactivity (SP-li) is decreased in duodenal samples of animals treated with a single dose of an ulcerogen such as dulcerozine, mepirizole or cysteamine. Unlike dulcerozine- or mepirizole-induced ulcers the degree of cysteamine-induced duodenal lesions is inversely correlated with the levels of duodenal SP-li. A significant decrease in duodenal SP-li was observed at 24 h, but not at 6 h after a single oral dose of cysteamine. These findings show that endogenous SP may play an important local role in duodenal ulcerogenesis.
Authors	S Evangelista, D Renzi, P Mantellini, C Surrenti, A Meli
Journal	Neuroscience letters (Neurosci Lett) Vol. 112 Issue 2-3 Pg. 352-5 (May 04 1990) ISSN: 0304-3940 [Print] Ireland
PMID	1694287 (Publication Type: Journal Article)
Chemical References	Pyrazoles Pyrimidines dulcerozine Substance P Epirizole Cysteamine
Topics	Animals Cysteamine Duodenal Ulcer (chemically induced, metabolism) Epirizole Female Immunohistochemistry Pyrazoles Pyrimidines Rats Rats, Inbred Strains Substance P (metabolism)

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