| Abstract | The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing ligand (TRAIL) expression by oxidative stress was shown in LN215 cells, an astroglioma cell line. Hydrogen peroxide (H2O2) treatment increased TRAIL expression in LN215 cells and H2O2-induced TRAIL augmented apoptosis in Peer cells, a cell line sensitive to TRAIL- mediated cell death. Our findings suggest that the upregulation of TRAIL in astroglial cells may abrogate immune cell effector functions. |
| Authors | Daeho Kwon, In-Hong Choi
(Affiliation: Department of Microbiology, Ajou University College of Medicine, Seoul, Korea.)
|
| Journal | Yonsei medical journal
(Yonsei Med J)
Vol. 47
Issue 4
Pg. 551-7
(Aug 31 2006)
ISSN: 0513-5796 Korea (South) |
| PMID | 16941746
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Immunosuppressive Agents
- TNF-Related Apoptosis-Inducing Ligand
- Cyclosporine
- Hydrogen Peroxide
- Ribonucleases
|
| Topics |
- Allergy and Immunology
- Anoxia
- Apoptosis
- Astrocytes
(metabolism)
- Cell Line, Tumor
- Cyclosporine
(pharmacology)
- Gene Expression Regulation, Neoplastic
- Humans
- Hydrogen Peroxide
(pharmacology)
- Immunosuppressive Agents
(pharmacology)
- Oxidative Stress
- Ribonucleases
(metabolism)
- T-Lymphocytes
(metabolism)
- TNF-Related Apoptosis-Inducing Ligand
(biosynthesis)
- Up-Regulation
|
